Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss.

Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss.

Model: Radiation-induced normal lung tissue toxicity after irradiation in mice, with acute vascular dysfunction and late endothelial cell loss and fibrosis; CCR2 knockout mice used as a genetic comparison

Bindarit counteracted radiation-induced Ccl2 expression, normalised endothelial cell morphology and vascular function, and limited lung inflammation and metastasis as acute effects; comparable vascular protection occurred in CCR2 knockout mice, and long-term Ccl2 signalling inhibition limited endot…

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