Limb remote ischemic post-conditioning mitigates brain recovery in a mouse model of ischemic stroke by regulating reactive astrocytic plasticity.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleImmediately after reperfusion
Model: Transient middle cerebral artery occlusion for 1 h followed by reperfusion, with assessment at 3 and 14 days
Remote ischaemic post-conditioning decreased hemispheric swelling, infarct volume and brain atrophy and increased neurological recovery and survival at 3 and 14 days, decreased GFAP and increased glutamine synthetase expression, downregulated GFAPalpha with a higher GFAPdelta/GFAPalpha ratio, and i…
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