THERAPY DOSSIER · th-30de9eb15021

Limb remote ischaemic post-conditioning

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06911385 ↗PHASE1/PHASE2not yet recruiting

Augmenting Cerebral Blood Flow Using a Novel Combined Treatment Approach in Patients With Ischemic Stroke

Stroke

Enrolment: 150 · Results not recorded

NCT07270887 ↗Phase not recordedrecruiting

Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASCVD Patients (RICMO-ASCVD)

ASCVD

Enrolment: 2800 · Results not recorded

NCT02381522 ↗NAcompleted

Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage

Brain Aneurysms

Enrolment: 26 · Results not recorded

NCT06536231 ↗NArecruiting

Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients

Critical Illness

Enrolment: 50 · Results not recorded

NCT07179887 ↗NArecruiting

Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation

Cerebral Autoregulation · Blood Pressure

Enrolment: 45 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29462606 ↗2018Reported benefit

Limb remote ischemic post-conditioning mitigates brain recovery in a mouse model of ischemic stroke by regulating reactive astrocytic plasticity.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleImmediately after reperfusion

Model: Transient middle cerebral artery occlusion for 1 h followed by reperfusion, with assessment at 3 and 14 days

Remote ischaemic post-conditioning decreased hemispheric swelling, infarct volume and brain atrophy and increased neurological recovery and survival at 3 and 14 days, decreased GFAP and increased glutamine synthetase expression, downregulated GFAPalpha with a higher GFAPdelta/GFAPalpha ratio, and i…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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