Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/6MaleIntracerebroventricular infusion10 ug/day (dose-dependent response tested)Beginning 15 min after injury; neurogenic effect retained with initiation delay…
Model: Controlled cortical impact traumatic brain injury
Continuous intracerebroventricular IGF-1 begun 15 min after controlled cortical impact produced a dose-dependent increase in hippocampal immature neurons, restoring density to sham levels, raised hippocampal Akt activation and improved motor and cognitive function over 7 days, with a therapeutic wi…
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