A novel rat model of extremity trauma for prehospital pain management research.
RatFractureFemurSprague-DawleyMaleIntravenous injectionMorphine 2 mg/kg, fentanyl 10 micrograms/kg, sufentanil 1 m…90 minutes after extremity trauma
Model: Extremity trauma induced under isoflurane anaesthesia by clamping retrofemoral tissues of one hindlimb for 30 seconds followed by closed fibula fracture, with no fixation surgery
After extremity trauma, paw withdrawal latency, paw withdrawal pressure and weight bearing fell by 61 plus or minus 4%, 64 plus or minus 8% and 65 plus or minus 4% respectively and remained depressed for 3 to 4 hours. Opioids increased paw withdrawal latency for at least 80 minutes, with sufentanil…
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