Continuous remote ischemic conditioning attenuates cognitive and motor deficits from moderate traumatic brain injury.
MouseTBIControlled cortical impactC57BLMalen = 24 mice, 12 per groupNon-invasive external compression of the hind limb using an occlusive bandSix 4-minute cycles per 24 hoursStarted 2 hours after traumatic brain injury
Model: Controlled cortical impact producing moderate traumatic brain injury
Remote ischaemic conditioning animals had a higher latency to fall than sham animals at all time points, significantly so from day 3 to day 21, and a significantly higher recognition index from day 1 to day 21. Hippocampal CA1 neurons in sham animals more often appeared shrunken with eosinophilic c…
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