THERAPY DOSSIER · th-239370d0a3e6

Continuous (daily) remote ischaemic conditioning

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07270887 ↗Phase not recordedrecruiting

Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASCVD Patients (RICMO-ASCVD)

ASCVD

Enrolment: 2800 · Results not recorded

NCT06536231 ↗NArecruiting

Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients

Critical Illness

Enrolment: 50 · Results not recorded

NCT07179887 ↗NArecruiting

Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation

Cerebral Autoregulation

Enrolment: 45 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29443855 ↗2018Reported benefit

Continuous remote ischemic conditioning attenuates cognitive and motor deficits from moderate traumatic brain injury.

MouseTBIControlled cortical impactC57BLMalen = 24 mice, 12 per groupNon-invasive external compression of the hind limb using an occlusive bandSix 4-minute cycles per 24 hoursStarted 2 hours after traumatic brain injury

Model: Controlled cortical impact producing moderate traumatic brain injury

Remote ischaemic conditioning animals had a higher latency to fall than sham animals at all time points, significantly so from day 3 to day 21, and a significantly higher recognition index from day 1 to day 21. Hippocampal CA1 neurons in sham animals more often appeared shrunken with eosinophilic c…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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