The neuroprotective effect of N-acetylcysteine in spinal cord-injured rats.
RatSpinal cord injuryCompressionWistar CMalen = 20 male rats, 10 per groupIntraperitoneal150 mg/kg body weight per doseFirst dose immediately after spinal cord injury
Model: Spinal cord injury produced by trepanation and compression with a pressure impactor
N-acetylcysteine treated rats showed some improvement in locomotor activity and spinal cord morphology, with a significantly lower hind paw angle of rotation, shorter lesion length and more Fluoro-Gold positive cells than controls. Lesion area was only slightly reduced and interlimb coordination di…
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