Vitamin D supplementation attenuates the behavioral scores of neuropathic pain in rats.
RatOtherSprague-DawleyMaleIntraperitonealAcute regimen 250, 500 and 1000 unit/kg; chronic regimen 10…Acute injections on the 7th, 14th and 21st postoperative days; chronic dosing s…
Model: Chronic constriction injury of the sciatic nerve producing thermal hyperalgesia, mechanical allodynia and cold allodynia
Acute vitamin D injections at 250, 500 and 1000 unit/kg did not attenuate mechanical allodynia, cold allodynia or heat hyperalgesia compared with the injury group. Daily administration of 1000 unit/kg from the first postoperative day until day 21 considerably attenuated cold allodynia and heat hype…
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