Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats.
RatOtherHannover-WistarMalen = 10 groups, n = 6 per groupIntraperitoneal50 mg/kg (low dose) and 300 mg/kg (high dose), 10 mg/mL; sp…Single injection at least 1 to 2 weeks after spared nerve injury or sham surger…
Model: Spared nerve injury of the left hind limb with ligation and section of the common peroneal and tibial nerves, sural nerve spared
Paracetamol at 300 mg/kg increased anxiety-like behaviour and anhedonia and impaired recognition memory in unoperated rats, while 50 mg/kg reduced mechanical hypersensitivity and anxiety in nerve-injured rats.
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