Drug · Cyclooxygenase inhibitor (target CHEMBL2094253); FAAH inhibitor (CHEMBL2243), which also generates the active metabolite AM404; AM404 opens the vanilloid receptor TRPV1 (CHEMBL4794). Black box warning (hepatotoxicity). Mannitol is the co-formulated excipient/stabiliser in the paracetamol-mannitol injection.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postoperative Delirium · Elderly · Non Cardiac Surgery
Enrolment: 1092 · Results not recorded
Osteoarthritis
Enrolment: 542 · Results not recorded
Osteoarthritis
Enrolment: 900 · Results not recorded
Cognitive Function
Enrolment: 100 · Results not recorded
Postoperative Analgesia
Enrolment: 90 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Crush injury produced by compression of the gastrocnemius muscle region for 2 or 24 hours
No significant differences in sodium, potassium, alanine aminotransferase or creatinine clearance between treatment groups, but acetaminophen reduced histopathological renal damage more than mannitol, with the combination intermediate.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Spared nerve injury of the left hind limb with ligation and section of the common peroneal and tibial nerves, sural nerve spared
Paracetamol at 300 mg/kg increased anxiety-like behaviour and anhedonia and impaired recognition memory in unoperated rats, while 50 mg/kg reduced mechanical hypersensitivity and anxiety in nerve-injured rats.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
