Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway.
MouseOtherKunmingMalen = 30 mice in 3 groups (control, acute lung injury, acute lung…Oral gavage80 mg/kg per dayStarted 14 days before blast injury
Model: Blast injury induced acute lung injury using a self-made explosive device with instantaneous shock wave overpressure of 321 plus or minus 24 PSI
Chitosan oligosaccharide pretreatment improved gas exchange, reduced pulmonary oedema, inflammation, oxidative stress and apoptosis, and increased DDAH1 while lowering ADMA and p38.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.