Tricalcium Phosphate and Chitosan as Bone Regenerator vs Autologous Graft in Mandibular Fracture Surgery
Mandibular Fractures
Enrolment: 24 · Results not recorded
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Device · No ChEMBL mechanism record; chitosan (INN poliglusam) is a deacetylated chitin polysaccharide used as a structural biomaterial, USAN 1991. Related ChEMBL entry CHEMBL4594468 chitosan low molecular weight (20-200 mPa.s), max_phase 3.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Mandibular Fractures
Enrolment: 24 · Results not recorded
Alveolar Ridge Preservation · Wound Healing
Enrolment: 26 · Results not recorded
Postpartum Hemorrhage
Enrolment: 196 · Results not recorded
Resorption of Tooth or Root
Enrolment: 36 · Results not recorded
Postoperative Pain
Enrolment: 24 · Results not recorded
Impaired Fasting Glucose, Newly-diagnosed Type 2 Diabetes
Enrolment: 60 · Results not recorded
Tooth Extraction · Bone Augmentation
Enrolment: 30 · Results not recorded
CSF Leakage
Enrolment: 1 · Results not recorded
Tympanic Membrane Perforation · Otitis Media
Enrolment: 44 · Results not recorded
Shellfish Allergy
Enrolment: 15 · Results not recorded
Diabetic Foot Ulcer
Enrolment: 320 · Results not recorded
Pain, Postoperative · Root Resorption · Necrotic Pulp
Enrolment: 108 · Results not recorded
Osseointegration Failure of Dental Implant
Enrolment: 20 · Results not recorded
Atopic Dermatitis
Enrolment: 165 · Results not recorded
Hypertrophic Scars
Enrolment: 120 · Results not recorded
Normal · Impaired Fasting Glucose · Impaired Glucose Tolerance
Enrolment: 37 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Standardised rat median nerve injury and repair using chitosan nerve guides and chitosan membranes; in vitro acutely axotomised autonomic neurones from primary sympathetic ganglia
Chitosan membranes significantly stimulated axon elongation from autonomic ganglia compared with control culture conditions, and chitosan coating and dissolution products significantly lowered proliferation of PC3, DU-145 and LN-Cap prostate cancer cells. In the rat median nerve model, tissue react…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: bilateral thermal burn wound
Chitosan films accelerated burn wound healing with increased collagen, granulation tissue, NOS activity and CD34 angiogenesis.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Blast injury induced acute lung injury using a self-made explosive device with instantaneous shock wave overpressure of 321 plus or minus 24 PSI
Chitosan oligosaccharide pretreatment improved gas exchange, reduced pulmonary oedema, inflammation, oxidative stress and apoptosis, and increased DDAH1 while lowering ADMA and p38.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Carbon tetrachloride-induced hepatic injury with hepatic necrosis
Chitosan lowered aminotransferase activities, cholesterol, triglycerides, free fatty acids and malondialdehyde, raised superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione, and reduced histological liver damage.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.