Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = Six groups; n = 6 per group for permeability and tissue ass…Intravenous50 mg/kg or 100 mg/kgPretreatment before the procedure or posttreatment after the procedure
Model: Trauma-haemorrhagic shock with femoral artery blood withdrawal holding blood pressure at 30 mmHg for 90 min, producing acute lung injury
Tranexamic acid at both doses before injury, and 100 mg/kg after injury, improved survival, reduced lung permeability and suppressed pulmonary inflammation and PARP1/NF-kappa B signalling.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.