The Effects of Memantine on Glutamic Receptor-Associated Nitrosative Stress in a Traumatic Brain Injury Rat Model.
RatTBIFluid percussionSprague-DawleyMaleIntraperitoneal20 mg/kg loading dose, then 1 mg/kg per doseLoading dose immediately after the onset of injury
Model: Fluid percussion traumatic brain injury under anaesthesia
Memantine significantly attenuated injury-induced motor and proprioceptive deficits and infarction volume, and reduced neuronal apoptosis, astrogliosis, microgliosis, neuronal nitric oxide synthase and 3-nitro-L-tyrosine positive neurons and inducible nitric oxide synthase in microglia and astrocyt…
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