Ubiquinol treatment for TBI in male rats: Effects on mitochondrial integrity, injury severity, and neurometabolism.
RatTBIUnspecifiedF344 (Fischer 344)MaleIntra-arterial30 minutes before injury in one group and 30 minutes after injury in another gr…
Model: Contusive traumatic brain injury
Ubiquinol given either before or after injury acutely reduced brain mitochondrial damage, apoptosis and the serum injury biomarkers glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1. In vivo proton magnetic resonance spectroscopy showed no attenuation of injury-induced neurometa…
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