HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.
MouseWoundC57BL/6Female
Model: Tooth extraction socket, comprising gingival epithelium and alveolar bone healing after extraction
Anti-HMGB1 antibody suppressed HMGB1 translocation in gingival epithelial and inflammatory cells, significantly reduced myeloperoxidase activity, CD31 and CD68 positive cell numbers, TRAP positive and osteocalcin positive cells, new bone area, and IL-1 beta and VEGF-A expression. The authors conclu…
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