THERAPY DOSSIER · th-e9ec9b8bab11

Anti-HMGB1 neutralising antibody

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29377249 ↗2018Reported harm

HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.

MouseWoundC57BL/6Female

Model: Tooth extraction socket, comprising gingival epithelium and alveolar bone healing after extraction

Anti-HMGB1 antibody suppressed HMGB1 translocation in gingival epithelial and inflammatory cells, significantly reduced myeloperoxidase activity, CD31 and CD68 positive cell numbers, TRAP positive and osteocalcin positive cells, new bone area, and IL-1 beta and VEGF-A expression. The authors conclu…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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