PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2018

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 29373946 ↗2018Mixed findings

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury.

RatSpinal cord injuryContusionLong-EvansApplied in the chronic phase after injury; outcomes assessed eight days after t…

Model: Chronic contusive spinal cord injury with established glial scar

Unmodified rose Bengal was more efficacious than the hydrocarbon-modified derivative while sparing intact tissue and increased serotonin at eight days, whereas the polyethylene glycol derivative was not taken up by cells and had no effect.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.