THERAPY DOSSIER · th-fd016c79b940

Rose Bengal (RB1) and derivatives modified with hydrocarbon (RB2) or polyethylene glycol (RB3)

Drug

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 1971
Development stage: Not recorded
ChEMBL record: CHEMBL1208422 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Rose bengal; Rose bengal free acid; NSC-10463; Rose bengal disodium (CHEMBL2359093); Rose bengal sodium I 131 (CHEMBL3989461)
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02288897 ↗PHASE3terminated

PV-10 Intralesional Injection vs Systemic Chemotherapy or Oncolytic Viral Therapy for Locally Advanced Cutaneous Melanoma

Cutaneous Melanoma

Enrolment: 20 · Results not recorded

NCT07743489 ↗PHASE3not yet recruiting

Light for Ulcer Management by Infection Elimination and Resistance Enhancement (LUMIERE) - Rose Bengal Photodynamic Therapy

Fusarium Keratitis

Enrolment: 434 · Results not recorded

NCT00521053 ↗PHASE2completed

Phase 2 Study of Intralesional PV-10 in the Treatment of Metastatic Melanoma

Melanoma

Enrolment: 80 · Results not recorded

NCT02557321 ↗PHASE1/PHASE2unknown

Phase 1b/2 Study of PV-10 Intralesional Injection With Systemic Immune Checkpoint Inhibition for Metastatic Melanoma

Melanoma

Enrolment: 50 · Results not recorded

NCT00219843 ↗PHASE1completed

Phase 1 Safety and Tolerability Study of Intralesional PV-10 Chemoablation in Metastatic Melanoma

Melanoma

Enrolment: 20 · Results not recorded

NCT01760499 ↗PHASE1completed

Detection of Immune Cell Infiltration Into Melanomas Treated by PV-10, a Feasibility Study

Melanoma

Enrolment: 15 · Results not recorded

NCT00237354 ↗PHASE1completed

Phase 1 Safety and Tolerability Study of PV-10 Chemoablation of Recurrent Breast Carcinoma

Breast Cancer

Enrolment: 15 · Results not recorded

NCT03031899 ↗Phase not recordedcompleted

Efficacy of Rose Bengal in Comparison With Toluidine Blue in Detection of Premalignant Lesions

Oral Leukoplakia · Oral Lichen Planus · Premalignant Lesion

Enrolment: 27 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29373946 ↗2018Mixed findings

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury.

RatSpinal cord injuryContusionLong-EvansApplied in the chronic phase after injury; outcomes assessed eight days after t…

Model: Chronic contusive spinal cord injury with established glial scar

Unmodified rose Bengal was more efficacious than the hydrocarbon-modified derivative while sparing intact tissue and increased serotonin at eight days, whereas the polyethylene glycol derivative was not taken up by cells and had no effect.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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