Fresh whole blood resuscitation does not exacerbate skeletal muscle edema and long-term functional deficit after ischemic injury and hemorrhagic shock.
RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyIntravascular resuscitationEarly resuscitation after haemorrhage and tourniquet application
Model: 42.5% arterial haemorrhage followed by 3 hours of tourniquet-induced hindlimb ischaemia and reperfusion
Hextend resuscitation worsened muscle oedema by about 11% and muscle strength deficit by about 20%, whereas fresh whole blood gave oedema and strength similar to tourniquet alone; all non-resuscitated rats died.
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