THERAPY DOSSIER · th-5cb71af59330

Fresh whole blood resuscitation compared with Hextend

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05634109 ↗Injury indicationPHASE3recruiting

Whole Blood vs. Blood Components Therapy in the Hemostatic Resuscitation of Severe Trauma Patients

Trauma · Trauma Injury · Trauma, Multiple

Enrolment: 220 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29370063 ↗2018Mixed findings

Fresh whole blood resuscitation does not exacerbate skeletal muscle edema and long-term functional deficit after ischemic injury and hemorrhagic shock.

RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyIntravascular resuscitationEarly resuscitation after haemorrhage and tourniquet application

Model: 42.5% arterial haemorrhage followed by 3 hours of tourniquet-induced hindlimb ischaemia and reperfusion

Hextend resuscitation worsened muscle oedema by about 11% and muscle strength deficit by about 20%, whereas fresh whole blood gave oedema and strength similar to tourniquet alone; all non-resuscitated rats died.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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