PRECLINICAL PUBLICATION · 2018

Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

System-specific optical stimulation of channelrhodopsin-expressing motor or sensory neurons

PMID 29363200 ↗2018Reported benefit

Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation.

MouseOtherChannelrhodopsin (ChR2) transgenic linesMale and femaleOptical (light) stimulation of the nerveAcute, combined with transection and repair of the sciatic nerve

Model: Sciatic nerve transection and repair

System-specific optical treatment increased the number of regenerating ChR2-positive motor and sensory neurons with no effect on ChR2-negative neurons.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.