THERAPY DOSSIER · th-dcfb4daa2888

System-specific optical stimulation of channelrhodopsin-expressing motor or sensory neurons

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29363200 ↗2018Reported benefit

Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation.

MouseOtherChannelrhodopsin (ChR2) transgenic linesMale and femaleOptical (light) stimulation of the nerveAcute, combined with transection and repair of the sciatic nerve

Model: Sciatic nerve transection and repair

System-specific optical treatment increased the number of regenerating ChR2-positive motor and sensory neurons with no effect on ChR2-negative neurons.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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