The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat.
RatSpinal cord injuryCompressionWistar albinoMalen = 48 male rats across control, acute and subacute stage groupsIntraperitonealFour hours after injury
Model: Spinal cord injury by temporary aneurysm clip compression following T7-8 laminectomy
Neither parecoxib nor methylprednisolone, alone or combined, improved histopathological grades or reduced malondialdehyde, caspase-3 or myeloperoxidase, although both reduced subacute TNF-alpha expression and methylprednisolone raised acute TGF-1beta expression.
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