Trial title not recorded
Rib Fractures
Enrolment: 17 · Results not recorded
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Drug · Cyclooxygenase-2 inhibitor (INHIBITOR); prodrug hydrolyzed to valdecoxib which selectively inhibits COX-2
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Rib Fractures
Enrolment: 17 · Results not recorded
Pain, Postoperative
Enrolment: 0 · Results not recorded
Gastrointestinal Cancer
Enrolment: 164 · Results not recorded
Post-operative Pain
Enrolment: 14 · Results not recorded
Preemptive Analgesia · Postoperative Pain
Enrolment: 178 · Results not recorded
Anterior Cruciate Ligament Rupture
Enrolment: 93 · Results not recorded
Pain · Inflammation
Enrolment: 246 · Results not recorded
Pain, Postoperative
Enrolment: 74 · Results not recorded
Sickle-Cell Disease with Crisis
Enrolment: 226 · Results not recorded
Pain, Postoperative
Enrolment: 220 · Results not recorded
Post-operative analgesia, TKA
Enrolment: 90 · Results not recorded
Shoulder Pain · Post-operative Pain
Enrolment: 160 · Results not recorded
Postoperative Pain
Enrolment: 58 · Results not recorded
Postoperative Analgesia
Enrolment: 90 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Spinal cord injury by temporary aneurysm clip compression following T7-8 laminectomy
Neither parecoxib nor methylprednisolone, alone or combined, improved histopathological grades or reduced malondialdehyde, caspase-3 or myeloperoxidase, although both reduced subacute TNF-alpha expression and methylprednisolone raised acute TGF-1beta expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: 45% total body surface area full-thickness scald burn (dorsum 10 s, abdomen 4 s in 98 to 100 degrees C water) with delayed fluid resuscitation using Hartmann's solution 40 mL/kg intraperitoneally, half at 1 h and half at 8 h after burn
Parecoxib at 1.0 mg/kg reduced plasma CINC-1, interleukin-6 and prostaglandin E2 metabolite and lung myeloperoxidase, gave the least structural organ damage and non-significantly improved 48 h survival (66.6% versus 56.5% for burn controls). Parecoxib at 10 mg/kg lowered circulating cytokines but s…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.