Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord.
RatSpinal cord injuryComplete transectionSprague-DawleyFemaleScaffold-delivered intraspinal transplantation, with immunosuppressionAt the time of injury repair; donor cells followed to 8 weeks (transection) and…
Model: Spinal cord transection model and, in a parallel study, acute contusive and compressive spinal cord injury
Grafted mesenchymal stem cells survived up to eight weeks and formed a perineurium-like sheath that enwrapped host myelin and axons, secreted trophic factors and superoxide dismutase-3 and preserved many intact regenerating axons at the injury site.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.