Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats.
RatTBIControlled cortical impactSprague-DawleyMaleSubcutaneous continuous infusionStarted after injury, covering the first 72 h
Model: Severe controlled cortical impact traumatic brain injury
Cyclosporine A and phenelzine each reduced mitochondrial 4-hydroxynonenal and acrolein, and phenelzine alone preserved mitochondrial respiratory control ratio and cytoskeletal integrity, but the combination did not maintain neuroprotective effects.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.