Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33.
MouseChemical/toxinC57BL/6 wild-type, ST2-deficient, Il33-deficient, IL-33 citrine reporterFemale
Model: Single acute ozone exposure (1 ppm for 1 h) causing lung epithelial barrier injury and neutrophilic inflammation
Administration of recombinant mouse IL-33 reduced neutrophil recruitment in Il33-deficient mice, and loss of IL-33 or ST2 worsened epithelial injury and myeloid inflammation, indicating IL-33/ST2 signalling protects the epithelial barrier after ozone exposure.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.