Genistein attenuates di-(2-ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO-1 following prepubertal exposure.
RatChemical/toxinSprague-Dawley (specific pathogen free)Malen = 48 rats in total, 6 per group across 8 groupsOral gavageGenistein 50 mg/kg body weight per day; di-(2-ethylhexyl) p…Co-administered with di-(2-ethylhexyl) phthalate from postnatal day 22 to postn…
Model: Di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury by daily gavage from postnatal day 22 to 35
Genistein co-administration partially reversed di-(2-ethylhexyl) phthalate-induced loss of testis weight, antioxidant enzyme activity and tubular vacuolation, and upregulated Nrf2 and HO-1, although values were not fully normalised to control.
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