PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2018

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury.

Mouse / Crush

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 29309057 ↗2018Outcome unclear

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury.

MouseCrushLimb / muscle crush

Model: Rhabdomyolysis-induced acute kidney injury (crush syndrome model)

The study identifies macrophage extracellular traps promoted by heme-activated platelets as a mediator of rhabdomyolysis-induced acute kidney injury and reports a new therapeutic tool for prevention, but the abstract does not name the agent, dose or route.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.4. Machine-extracted fields require source verification.