Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses.
MouseTBIWeight-drop / impact-accelerationMale5 g/kg30 min before injury or 20 min after injury
Model: Closed weight-drop traumatic brain injury of moderate (2 cm falling height) or severe (3 cm falling height) severity
Ethanol given 30 min before moderate traumatic brain injury reduced neurological impairment, accelerated recovery and preserved neuronal numbers, with attenuated induction of a subset of immediate early genes, whereas post-injury administration and severe injury showed little or no benefit.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.