Evaluation of Detergent-Free and Detergent-Based Methods for Decellularization of Murine Skin.
MouseWoundTopical transplantation onto wound
Model: Full-thickness skin wound covered with acellular dermal matrix (transplantation model)
All decellularisation methods removed cells and supported fibroblast growth and migration. Sulfated glycosaminoglycan content fell significantly only with ionic detergent. All detergent-based methods significantly reduced scaffold mechanical strength and elastin content, whereas the detergent-free…
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