THERAPY DOSSIER · th-a0b774a28ff9

Acellular dermal matrix prepared by detergent-free, nonionic detergent or anionic (ionic) detergent decellularisation of murine skin

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01561287 ↗PHASE4completed

Dermal autograft compared to commercially available dermal allograft in breast reconstruction

Mastectomy Related Lymphedema · Breast Reconstruction · Breast Cancer

Enrolment: 48 · Results not recorded

NCT01987700 ↗PHASE4completed

Flex HD human acellular dermal matrix vs Strattice porcine acellular dermal matrix in repair of large abdominal wall hernias

Hernia of Abdominal Wall

Enrolment: 120 · Results not recorded

NCT06241196 ↗PHASE2unknown

Vestibular socket therapy using acellular dermal matrix versus connective tissue graft in immediate implants

Immediate Implant

Enrolment: 10 · Results not recorded

NCT01572298 ↗NAcompleted

Alveolar ridge augmentation using tenting screws, acellular dermal matrix and combination particulate grafts

Dental Alveolus · Oral Surgical Procedures, Preprosthetic

Enrolment: 34 · Results not recorded

NCT03163654 ↗NAcompleted

Novel porcine dermal matrix vs connective tissue graft for multiple adjacent gingival recessions

Recession, Gingival

Enrolment: 16 · Results not recorded

NCT01959867 ↗NAwithdrawn

Two-stage breast reconstruction with and without SurgiMend PRS fetal bovine collagen matrix

Breast Cancer

Enrolment: 0 · Results not recorded

NCT02521623 ↗NAcompleted

SurgiMend vs Strattice in direct to implant breast reconstruction

Breast Neoplasms

Enrolment: 60 · Results not recorded

NCT01175720 ↗NAcompleted

Two surgical techniques with acellular dermal matrix graft in the treatment of gingival recessions

Gingival Recession

Enrolment: 15 · Results not recorded

NCT02139748 ↗NAcompleted

Implant placement with acellular dermal matrix allograft vs allograft plus bovine-derived xenograft

Dental Implants

Enrolment: 28 · Results not recorded

NCT07345026 ↗NAnot yet recruiting

Acellular dermal matrix (SureDerm BCS) in breast cancer patients undergoing breast-conserving surgery

Breast Neoplasms · Mastectomy, Segmental

Enrolment: 116 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29303417 ↗2018Mixed findings

Evaluation of Detergent-Free and Detergent-Based Methods for Decellularization of Murine Skin.

MouseWoundTopical transplantation onto wound

Model: Full-thickness skin wound covered with acellular dermal matrix (transplantation model)

All decellularisation methods removed cells and supported fibroblast growth and migration. Sulfated glycosaminoglycan content fell significantly only with ionic detergent. All detergent-based methods significantly reduced scaffold mechanical strength and elastin content, whereas the detergent-free…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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