The beta-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1beta administration to rats.
RatOtherWistarMaleIntraperitoneal0.5 mg/kgOne hour prior to intra-striatal IL-1beta administration
Model: Acute brain injury induced by stereotactic intra-striatal administration of IL-1beta (100 ng)
Clenbuterol attenuated all IL-1beta-induced changes in the striatum, including MBS-2 immunoreactivity and TUNEL-positive staining, and also reduced IL-1beta-induced hepatic TNF-alpha expression and the rise in circulating CINC-1, indicating suppression of both central and peripheral inflammatory re…
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