Protective Effects of Selenium on Cyclophosphamide-Induced Oxidative Stress and Kidney Injury.
RatChemical/toxinSprague-DawleyMalen = 42 rats in six groups of sevenIntraperitoneal0.5 or 1 mg/kgCo-treatment with cyclophosphamide
Model: Cyclophosphamide-induced acute nephrotoxicity (single 150 mg/kg cyclophosphamide)
Cyclophosphamide alone raised creatinine, cystatin C, total oxidant state and oxidative stress index and lowered total antioxidant capacity. Co-treatment with selenium reduced the histological damage, and the biochemical findings supported the microscopic observations, indicating a protective effec…
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