Evidence & regulatory context
- Mechanism
- Nutritional supplement.
- Target
- Not recorded
- Injury models
- Radiation · Chemical/toxin
- Reported indication
- Selenium deficiency / trace-element supplementation, including in parenteral nutrition (selenious acid injection FDA-approved 2019)
- First approval
- 2019
- Development stage
- Approved trace-element supplement; acute critical-illness/inflammation repurposing without benefit
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Selenious acid; Sodium selenite (CHEMBL112302); Monohydrated selenium dioxide; Selenium (as selenious acid)
- Note
- Not recorded
Clinical trials 4
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Influence Of Early Antioxidant Supplements On Clinical Evolution And Organ Function In Critically Ill Cardiac Surgery, Major Trauma And Subarachnoid Hemorrhage Patients
Critically Ill Patients · Cardiac Surgery · Trauma · Subarachnoid Hemorrhage
Enrolment: 200 · Results not recorded
Does Antioxidant Supplementation to Endometriotic Women Undergoing ICSI Could Alter Reactive Oxygen Species (ROS) Levels and Affect Pregnancy Outcome
Endometriosis
Enrolment: 50 · Results not recorded
The Role of Sodium Selenite Supplementation in Patients With Locally Advanced Head and Neck Cancer Undergoing Concurrent Chemoradiotherapy
Head and Neck Squamous Cell Carcinoma · Selenium · Sodium Selenite
Enrolment: 60 · Results not recorded
Endothelial Dysfunction and Selenium Status in Children With Acute Systemic Inflammatory
Endothelial Dysfunction · Regulation of Acute Inflammatory Response · Selenium Deficiency
Enrolment: 114 · Results not recorded
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseRadiationHairlessFemaleOralSupplementation before and during ultraviolet exposure
Model: Ultraviolet light irradiation of skin producing acute and sub-acute inflammatory reaction and pigmentation
Selenium-supplemented hairless mice were considerably more resistant than unsupplemented animals to the acute and sub-acute inflammatory and pigmentary skin reactions to ultraviolet light. No quantitative data are given in the abstract.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
RatChemical/toxinSprague-DawleyMalen = 42 rats in six groups of sevenIntraperitoneal0.5 or 1 mg/kgCo-treatment with cyclophosphamide
Model: Cyclophosphamide-induced acute nephrotoxicity (single 150 mg/kg cyclophosphamide)
Cyclophosphamide alone raised creatinine, cystatin C, total oxidant state and oxidative stress index and lowered total antioxidant capacity. Co-treatment with selenium reduced the histological damage, and the biochemical findings supported the microscopic observations, indicating a protective effec…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.