Nicotinic Acetylcholine Receptor Alpha7 Subunit Mediates Vagus Nerve Stimulation-Induced Neuroprotection in Acute Permanent Cerebral Ischemia by a7nAchR/JAK2 Pathway.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 108 rats allocated, 16 analysed per group across six groups…Direct electrical stimulation via electrodes wrapped around the left vagus nerve; antagonist by left lateral ventricle injection; agonist intraperitonealStimulation pulses of 0.5 mA in 30 s trains, 0.5 ms pulse w…Vagus nerve stimulation initiated 30 min after PMCAO surgery; alpha-bungarotoxi…
Model: Permanent left middle cerebral artery occlusion by intraluminal monofilament nylon suture (PMCAO)
Vagus nerve stimulation improved neurological function and reduced infarct volume after permanent middle cerebral artery occlusion, and raised a7nAChR, p-JAK2 and p-STAT3 in the ischaemic penumbra. Blockade of a7nAChR with alpha-bungarotoxin abolished these benefits, with brain infarct volume perce…
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