Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Strategies to Understand and Optimize the Antidepressant Effects of Psilocybin, With taVNS (OPTIMIZE)
Depression
Enrolment: 141 · Results not recorded
Safety and Treatment Results of Early (<6 Months) Versus Late (>6 Months) Vagus Nerve Stimulation for Post-stroke Motor Rehabilitation
Stroke · Motor Rehabilitation
Enrolment: 100 · Results not recorded
Efficacy of Trans-auricular Vagus Nerve Stimulation on Upper Extremity Motor Recovery in Stroke Survivors
Stroke
Enrolment: 30 · Results not recorded
Transcutaneous Vagal Nerve Stimulation for Persistent Atrial Fibrillation (VAST-AF)
Atrial Fibrillation
Enrolment: 120 · Results not recorded
Acute Cardiovascular Effects of Transcutaneous Auricular Vagus Nerve Stimulation
Vagus Nerve Stimulation
Enrolment: 20 · Results not recorded
Effectiveness of Transcutaneous Electrical (Vagus) Stimulation on the Autonomic and Cardiovascular System in Healthy Young People
Healthy Volunteers · Cardiovascular System · Autonomic Nervous System
Enrolment: 30 · Results not recorded
Transcutaneous Auricular Vagus Nerve Stimulation on Edema, Grip Strength, Dexterity and Quality of Life in Upper Extremity Lymphedema
Lymphedema · Edema · Grip Strength · Quality of Life
Enrolment: 27 · Results not recorded
Effect of Auricular Vagus Nerve Stimulation on Lower Limb Muscle Strength and Balance in Non-elite Athletes
Muscle Strength · Balance
Enrolment: 30 · Results not recorded
Non-invasive Auricular Vagal Nerve Stimulation Versus Circuit Weight Training on Nutritional Modulation in Metabolic Syndrome
Metabolic Syndrome
Enrolment: 70 · Results not recorded
Brown Adipose Tissue After Vagus Nerve Stimulation (implanted VNS on/off)
Obesity
Enrolment: 5 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 108 rats allocated, 16 analysed per group across six groups…Direct electrical stimulation via electrodes wrapped around the left vagus nerve; antagonist by left lateral ventricle injection; agonist intraperitonealStimulation pulses of 0.5 mA in 30 s trains, 0.5 ms pulse w…Vagus nerve stimulation initiated 30 min after PMCAO surgery; alpha-bungarotoxi…
Model: Permanent left middle cerebral artery occlusion by intraluminal monofilament nylon suture (PMCAO)
Vagus nerve stimulation improved neurological function and reduced infarct volume after permanent middle cerebral artery occlusion, and raised a7nAChR, p-JAK2 and p-STAT3 in the ischaemic penumbra. Blockade of a7nAChR with alpha-bungarotoxin abolished these benefits, with brain infarct volume perce…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
