Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Calcitonin gene-related peptide knockout (CGRP-/-) and wild typeMale
Model: Middle cerebral artery occlusion and bilateral common carotid artery stenosis
CGRP knockout mice showed slower cerebral blood flow recovery, greater neuronal death and demyelination, higher inflammatory cytokines and oxidative stress, less compensatory capillary growth and poorer reference memory than wild type. CGRP administration promoted cerebral blood flow recovery after…
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