Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide: A Randomized Clinical Trial
Migraine Aura · Migraine With Aura
Enrolment: 21 · Results not recorded
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Hormone
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Migraine Aura · Migraine With Aura
Enrolment: 21 · Results not recorded
Migraine
Enrolment: 40 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Transient middle cerebral artery occlusion (2 h) with 46 h reperfusion
CGRP reduced brain oedema, infarct volume and blood-brain barrier disruption after focal cerebral ischaemia-reperfusion in rats, partly via AQP4 downregulation.
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Model: Middle cerebral artery occlusion and bilateral common carotid artery stenosis
CGRP knockout mice showed slower cerebral blood flow recovery, greater neuronal death and demyelination, higher inflammatory cytokines and oxidative stress, less compensatory capillary growth and poorer reference memory than wild type. CGRP administration promoted cerebral blood flow recovery after…
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Model: Hyperoxia-induced neonatal lung injury (95% oxygen for 14 days)
Survival improved from 73% under hyperoxia to 84% with CGRP (93% in normoxia). CGRP alleviated hyperoxia-induced histomorphological change, reduced bronchoalveolar lavage leukocyte counts and total protein, restored superoxide dismutase activity, lowered malondialdehyde, and reduced TNF-alpha mRNA…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.