Neuroserpin restores autophagy and promotes functional recovery after acute spinal cord injury in rats.
RatSpinal cord injuryCompressionSprague-DawleyMaleIntrathecal injectionImmediately after spinal cord injury
Model: Clip compression spinal cord injury
Neuroserpin markedly decreased LC3-II and p62 at 72 h after injury, reduced autophagosome accumulation, improved BBB locomotor scores and increased the number of anterior horn motor neurons, indicating restoration of autophagic flux and functional recovery.
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