Taurine supplementation reduces neuroinflammation and protects against white matter injury after intracerebral hemorrhage in rats.
RatHaemorrhage/shockUnspecifiedSprague-DawleyMaleIntravenousHigh dosage 50 mg/kg; different concentrations tested10 min after intracerebral haemorrhage
Model: Collagenase-induced intracerebral haemorrhage
Taurine at 50 mg/kg significantly attenuated functional deficits, reduced brain oedema and haemorrhagic lesion volume, ameliorated neuronal and white matter injury, and reduced neutrophil infiltration, glial activation and inflammatory mediator expression, in association with increased hydrogen sul…
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