THERAPY DOSSIER · th-cd9d60441bd3

Taurine

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL239243 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Taurine; Aminoethylsulfonic acid; 2-aminoethanesulfonic acid; Taurate; NSC-32428; FEMA NO. 3813
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06123455 ↗PHASE2unknown

Taurine + Sintilimab + Chemo vs Sintilimab+Chemo in Advanced Gastric Cancer

Gastric Cancer

Enrolment: 60 · Results not recorded

NCT07263607 ↗PHASE2not yet recruiting

Multicenter Study on Taurine Treatment for Multiple Sclerosis

Multiple Sclerosis (MS) Relapsing Remitting

Enrolment: 80 · Results not recorded

NCT00217165 ↗PHASE2completed

Taurine as an Anti-manic Agent (double-blind placebo-controlled)

Bipolar Disorder · Mania

Enrolment: 60 · Results not recorded

NCT06639711 ↗PHASE1/PHASE2active not recruiting

Taurine Affects Progression of Senile Cataract (single-arm pre-post)

Cataract

Enrolment: 50 · Results not recorded

NCT07730255 ↗NAactive not recruiting

Exercise +/- Taurine on Intramuscular Fat in Older Women With Obesity

Obesity

Enrolment: 44 · Results not recorded

NCT04772508 ↗NAcompleted

Subgingival Amnion Membrane +/- Taurine Adjunct to SRP in Chronic Periodontitis

Periodontitis

Enrolment: 45 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29256178 ↗2017Reported benefit

Taurine supplementation reduces neuroinflammation and protects against white matter injury after intracerebral hemorrhage in rats.

RatHaemorrhage/shockUnspecifiedSprague-DawleyMaleIntravenousHigh dosage 50 mg/kg; different concentrations tested10 min after intracerebral haemorrhage

Model: Collagenase-induced intracerebral haemorrhage

Taurine at 50 mg/kg significantly attenuated functional deficits, reduced brain oedema and haemorrhagic lesion volume, ameliorated neuronal and white matter injury, and reduced neutrophil infiltration, glial activation and inflammatory mediator expression, in association with increased hydrogen sul…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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