Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.

Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.

Model: Fixed pressure haemorrhagic shock with laparotomy inducing lung injury

Both mesenchymal stem cells and their extracellular vesicles significantly decreased haemorrhagic shock induced lung vascular permeability and reduced RhoA activation. In vitro, mesenchymal stem cell conditioned medium but not extracellular vesicles prevented thrombin-induced endothelial permeabili…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.