THERAPY DOSSIER · th-937f57d91454

Extracellular vesicles derived from human bone marrow mesenchymal stem cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03384433 ↗PHASE1/PHASE2unknown

Safety and Efficacy of Allogenic Mesenchymal Stem Cell-Derived Exosome on Disability of Patients With Acute Ischemic Stroke

Cerebrovascular Disorders

Enrolment: 5 · Results not recorded

NCT05813379 ↗PHASE1/PHASE2unknown

Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Anti Aging

Enrolment: 20 · Results not recorded

NCT05176366 ↗PHASE1terminated

Phase I Study of ExoFlo, an Ex Vivo Culture-expanded Adult Allogeneic Bone Marrow MSC-Derived Extracellular Vesicle Isolate, for Medically Refractory Ulcerative Colitis

Ulcerative Colitis · Inflammatory Bowel Diseases

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29251710 ↗2018Reported benefit

Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.

MouseHaemorrhage/shockControlledC57BL/6Intravenous

Model: Fixed pressure haemorrhagic shock with laparotomy inducing lung injury

Both mesenchymal stem cells and their extracellular vesicles significantly decreased haemorrhagic shock induced lung vascular permeability and reduced RhoA activation. In vitro, mesenchymal stem cell conditioned medium but not extracellular vesicles prevented thrombin-induced endothelial permeabili…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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