Human adipose-derived stem cell treatment modulates cellular protection in both in vitro and in vivo traumatic brain injury models.
RatTBIBlast / overpressureSprague-DawleyMaleIntravenousWithin 3 hours of injury
Model: Frontal closed-head traumatic brain injury; in vitro scratch injury of SH-SY5Y neuroblastoma cells
In vitro, conditioned medium reduced cell death, increased viability and mitochondrial function and decreased IL-1 beta. In vivo, treated animals had lower brain TNF-alpha (0.47 +/- 0.01 vs 0.67 +/- 0.04 ratio to total protein, p < 0.01) and lower beta-amyloid precursor protein (fluorescence ratio…
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