Treatment of Sequelae Caused by Severe Brain Injury With Autologous Adipose-derived Mesenchymal Stem Cells
The Sequelae Caused by Severe Brain Injury
Enrolment: 1 · Results not recorded
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Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
The Sequelae Caused by Severe Brain Injury
Enrolment: 1 · Results not recorded
Knee Osteoarthritis
Enrolment: 165 · Results not recorded
Ophthalmological Disorder · Corneal Dystrophy · Keratoconus
Enrolment: 15 · Results not recorded
Crohn's Fistula
Enrolment: 40 · Results not recorded
Androgenetic Alopecia
Enrolment: 22 · Results not recorded
Respiratory Tract Diseases
Enrolment: 0 · Results not recorded
Low Back Pain
Enrolment: 10 · Results not recorded
Pelvic Organ Prolapse
Enrolment: 18 · Results not recorded
Perianal Fistula · Primary; Complex
Enrolment: 6 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Frontal closed-head traumatic brain injury; in vitro scratch injury of SH-SY5Y neuroblastoma cells
In vitro, conditioned medium reduced cell death, increased viability and mitochondrial function and decreased IL-1 beta. In vivo, treated animals had lower brain TNF-alpha (0.47 +/- 0.01 vs 0.67 +/- 0.04 ratio to total protein, p < 0.01) and lower beta-amyloid precursor protein (fluorescence ratio…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Four circular full-thickness skin defects created on the dorsum
Healing time decreased in the adipose-derived, bone-marrow-derived and skin graft groups with lower alpha-smooth muscle actin and higher fibroblast growth factor, although scar area was smallest in the saline group.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.