Combinatorial therapy with two pro-coagulants and one osmotic agent reduces the extent of the lesion in the acute phase of spinal cord injury in the rat.

Combinatorial therapy with two pro-coagulants and one osmotic agent reduces the extent of the lesion in the acute phase of spinal cord injury in the rat.

Model: Weight-drop spinal cord injury at the 12th thoracic vertebra

Compared with control, the triple therapy significantly reduced parenchymal haemorrhage (p < 0.05) and increased the total amount of intact neural tissue at 24 h (p = 0.003).

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