Systemic recovery and therapeutic effects of transplanted allogenic and xenogenic mesenchymal stromal cells in a rat blunt chest trauma model.
RatOtherWistarMaleSingle dose; cell number not stated in the abstractImmediately after induction of blunt chest trauma
Model: Blunt chest trauma (TxT) causing lung contusion and acute lung injury
Human mesenchymal stromal cells reduced the injury score at 24 h by at least 50 per cent versus untreated trauma and lowered pro-inflammatory cytokines and chemokines while raising TNFAIP6. Rat mesenchymal stromal cells did not show these therapeutic effects except for TNFAIP6. By 5 days cytokine l…
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